解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::FGFR1 (fibroblast growth factor receptor 1) regulates many key cellular responses including proliferation, migration and differentiation through activation of signaling pathways. Irregularities in FGFR1 signaling have been implicated in several pathological conditions, including human cancer. In order to discover nove...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.425
更新日期:2014-10-02 00:00:00
abstract::Krüppel-like factor 8 (KLF8) is a transcriptional factor critical for metastatic progression of breast cancer. Epithelial stromal interaction 1 (EPSTI1), a recently identified stromal fibroblast-induced gene in non-invasive breast cancer cells is highly overexpressed in invasive breast carcinomas. The function and reg...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.415
更新日期:2014-09-25 00:00:00
abstract::Cancer cells acquire several traits that allow for their survival and progression, including the ability to evade the host immune response. However, the mechanisms by which cancer cells evade host immune responses remain largely elusive. Here we study the phenomena of immune evasion in malignant melanoma cells. We fin...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.409
更新日期:2014-09-18 00:00:00
abstract::The retinoblastoma gene product (pRb) controls proliferation and differentiation processes in stratified epithelia. Importantly, and in contrast to other tissues, Rb deficiency does not lead to spontaneous skin tumor formation. As the cyclin-dependent kinase inhibitor p21 regulates proliferation and differentiation in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.417
更新日期:2014-09-11 00:00:00
abstract::The cysteine protease cathepsin B (CTSB) is frequently overexpressed in human breast cancer and correlated with a poor prognosis. Genetic deficiency or pharmacological inhibition of CTSB attenuates tumor growth, invasion and metastasis in mouse models of human cancers. CTSB is expressed in both cancer cells and cells ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.395
更新日期:2014-09-04 00:00:00
abstract::The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully characterized, and the mechanisms of DAB2 dysregulation in lung cancer are not defined. Here we show that low D...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.381
更新日期:2014-08-21 00:00:00
abstract::The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but not by SUMO2/3 at multiple sites. We show that FOXM1 SUMOylation...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.546
更新日期:2014-08-21 00:00:00
abstract::The mitotic spindle is assembled by the coordinated action of centrosomes and kinetochore microtubules. An evolutionally conserved protein family, transforming acidic coiled-coil (TACC), has been shown to be involved in this process. In humans, TACC3 is aberrantly expressed in a variety of human cancers, but its biolo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.382
更新日期:2014-08-14 00:00:00
abstract::Loss of the DNA mismatch repair (MMR) protein MSH3 leads to the development of a variety of tumors in mice without significantly affecting survival rates, suggesting a modulating role for the MutSβ (MSH2-MSH3) complex in late-onset tumorigenesis. To better study the role of MSH3 in tumor progression, we crossed Msh3(-...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.365
更新日期:2014-07-24 00:00:00
abstract::Dysregulation of cellular signaling pathways can lead to colon cancer. However, research on the key signaling effectors or regulators in colon carcinogenesis is limited. Casein kinase-2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is crucial during adult bone formation and is a promising drug target for osteo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.340
更新日期:2014-07-10 00:00:00
abstract::Tumor metastasis is the leading cause of death among breast cancer patients. PELP1 (proline, glutamic acid and leucine rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer progression to metastasis and is an independent prognostic predictor of shorter survival of breast cancer pat...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.332
更新日期:2014-07-10 00:00:00
abstract::Myristoylated Alanine-Rich C Kinase Substrate (MARCKS), a substrate of protein kinase C, is a key regulatory molecule controlling mucus granule secretion by airway epithelial cells as well as directed migration of leukocytes, stem cells and fibroblasts. Phosphorylation of MARKCS may be involved in these responses. How...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.336
更新日期:2014-07-10 00:00:00
abstract::The growth and dissemination of tumors rely on an altered vascular network, which supports their survival and expansion and provides accessibility to the vasculature and a route of transport for metastasizing tumor cells. The remodeling of vascular structures through generation of new vessels (for example, via tumor a...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.304
更新日期:2014-07-03 00:00:00
abstract::Biomarkers that predict disease progression might assist the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. Here, we investigated the role of collagen type XI alpha 1 (COL11A1) in cell invasiveness and tumor formation and the prognostic impact of COL11A1 expression in ovar...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.307
更新日期:2014-06-26 00:00:00
abstract::Superior cervical ganglia 10 (SCG10), as a microtubule (MT) destabilizer, maintains MT homeostasis and has a critical role in neuronal development, but its function in tumorigenesis has not been characterized. In the present study, we demonstrated that p21-activated kinase 4 (PAK4)-mediated SCG10 phosphorylation regul...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.296
更新日期:2014-06-19 00:00:00
abstract::Despite the progress made in targeted anticancer therapies in recent years, challenges remain. The identification of new potential targets will ensure that the arsenal of cancer therapies continues to expand. FAM83B was recently discovered in a forward genetic screen for novel oncogenes that drive human mammary epithe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.293
更新日期:2014-06-19 00:00:00
abstract::Heterozygous germline mutations in PHOX2B, a transcriptional regulator of sympathetic neuronal differentiation, predispose to diseases of the sympathetic nervous system, including neuroblastoma and congenital central hypoventilation syndrome (CCHS). Although the PHOX2B variants in CCHS largely involve expansions of th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.290
更新日期:2014-06-19 00:00:00
abstract::Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple mechanisms, one of which is to express constitutively active androgen receptor (AR) splice variants lacking the ligand-binding domain. AR splice variant 7 (AR-V7, also termed AR3) is the most abundantly expressed variant that drives p...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.284
更新日期:2014-06-12 00:00:00
abstract::One of the hallmarks of malignancy is the polarization of tumor-associated macrophages (TAMs) from a pro-immune (M1-like) phenotype to an immune-suppressive (M2-like) phenotype. However, the molecular basis of the process is still unclear. MicroRNA (miRNA) comprises a group of small, non-coding RNAs that are broadly e...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.258
更新日期:2014-06-05 00:00:00
abstract::SMARCB1 (Snf5/Ini1/Baf47) is a potent tumor suppressor, the loss of which serves as the diagnostic feature in malignant rhabdoid tumors (MRT) and atypical teratoid/rhabdoid tumors (AT/RT), two highly aggressive forms of pediatric neoplasms. SMARCB1 is a core subunit of Swi/Snf chromatin remodeling complexes, and loss ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.261
更新日期:2014-06-05 00:00:00
abstract::Recognition and elimination of malignant cells by cytotoxic T lymphocytes depends on antigenic peptides generated by proteasomes. It has been established that impairment of the immunoproteasome subunits, that is, PSMB8, PSMB9 and PSMB10 (PSMBs), is critical for malignant cells to escape immune recognition. We report h...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.224
更新日期:2014-05-22 00:00:00
abstract::Integrin α3β1 regulates adhesive interactions of cells with laminins and have a critical role in adhesion-dependent cellular responses. Here, we examined the role of α3β1-integrin in ErbB2-dependent proliferation of breast cancer cells in three-dimensional laminin-rich extracellular matrix (3D lr-ECM). Depletion of α3...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.231
更新日期:2014-05-22 00:00:00
abstract::Antimicrobial peptides, such as the cathelicidin LL-37/hCAP-18 and its mouse homolog cathelicidin-related antimicrobial peptide (CRAMP), are important effectors of the innate immune system with direct anti-bacterial activity. Cathelicidin is possibly involved in the regulation of tumor cell growth. The aim of this stu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.248
更新日期:2014-05-22 00:00:00
abstract::Poor-prognosis oestrogen receptor-positive breast cancer is characterised by the presence of high-level focal amplifications. We utilised a focused small interfering RNA screen in 14 breast cancer cell lines to define genes that were pathogenic in three genomic regions focally amplified in oestrogen receptor-positive ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.202
更新日期:2014-05-08 00:00:00
abstract::Melanoma progression is typically depicted as a linear and stepwise process in which metastasis occurs relatively late in disease progression. Significant evidence suggests that in a subset of melanomas, progression is much more complex and less linear in nature. Epidemiologic and experimental observations in melanoma...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.194
更新日期:2014-05-08 00:00:00
abstract::Desmoglein 3 (Dsg3), the pemphigus vulgaris antigen, has recently been shown to be upregulated in squamous cell carcinoma (SCC) and has been identified as a good tumor-specific marker for clinical staging of cervical sentinel lymph nodes in head and neck SCC. However, little is known about its biological function in c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.186
更新日期:2014-05-01 00:00:00
abstract::The proto-oncogene BMI1 and its product, Bmi1, is overexpressed in various types of tumors, particularly in aggressive tumors and tumors resistant to conventional chemotherapy. BMI1/Bmi1 is also crucially involved in cancer-initiating cell maintenance, and is recurrently upregulated in mantle cell lymphoma (MCL), espe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.177
更新日期:2014-04-24 00:00:00
abstract::Matrix metalloprotease-1 (MMP1) is an important mediator of tumorigenesis, inflammation and tissue remodeling through its ability to degrade critical matrix components. Recent studies indicate that stromal-derived MMP1 may exert direct oncogenic activity by signaling through protease-activated receptor-1 (PAR1) in car...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.157
更新日期:2014-04-24 00:00:00
abstract::The Src family kinases c-Src, and its downstream effectors, the Rho family of small GTPases RhoA and Jun N-terminal kinase (JNK) have a significant role in tumorigenesis. In this report, using the Drosophila wing disc epithelium as a model system, we demonstrate that the actin-Capping Protein (CP) αβ heterodimer, whic...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.155
更新日期:2014-04-17 00:00:00
abstract::Cell proliferation and differentiation are closely coupled. However, we previously showed that overexpression of cyclin-dependent kinase (Cdk6) blocks chondrocyte differentiation without affecting cell-cycle progression in vitro. To investigate whether Cdk6 inhibits chondrocyte differentiation in vivo, we generated ch...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.130
更新日期:2014-04-03 00:00:00
abstract::Met tyrosine kinase has been implicated in tumorigenesis and metastasis; its overexpression and deregulation is often observed in cancer. Although Met's functions in cell motility has been studied extensively, its involvement in bleb-based, amoeboid motility is yet to be determined. The aim of this work is to study th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.138
更新日期:2014-04-03 00:00:00
abstract::A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance t...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.121
更新日期:2014-04-03 00:00:00
abstract::The sirtuins (SIRT 1-7) comprise a family of NAD⁺-dependent protein-modifying enzymes with activities in lysine deacetylation, adenosinediphospho(ADP)-ribosylation, and/or deacylation. These enzymes are involved in the cell's stress response systems and in regulating gene expression, DNA damage repair, metabolism and ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.120
更新日期:2014-03-27 00:00:00
abstract::P63, a p53 family member, is expressed as TA and ΔN isoforms. Interestingly, both TAp63 and ΔNp63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for survival of some epithelial cell lineages, and lack of p63 leads to loss of epidermis and other epithelia in human...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.101
更新日期:2014-03-20 00:00:00
abstract::The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a non-transforming form of v-erbA (S61G), were compared using serial analysis of gene expression and some, but not a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.93
更新日期:2014-03-20 00:00:00
abstract::Histone deacetylase inhibitors (HDACis) are a promising class of anticancer epigenetic drugs, however, molecular factors influencing the responses of individual tumors to HDACi therapies remain obscure. Here, we sought to identify genes associated with HDACi resistance in gastric cancer. Treating a panel of 17 gastric...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.104
更新日期:2014-03-20 00:00:00
abstract::Ataxia Telangiectasia Mutated (ATM) kinase, a central regulator of the DNA damage response, regulates the activity of several E3-ubiquitin ligases, and the ubiquitination-proteasome system is a consistent target of ATM. ITCH is an E3-ubiquitin ligase that modulates the ubiquitination of several targets, therefore part...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.52
更新日期:2014-02-27 00:00:00
abstract::The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of v...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.80
更新日期:2014-02-20 00:00:00
abstract::MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, but their role in head and neck cancer development and progression is not well defined. We aimed to determine whether specific miRNAs and their target mRNAs contribute to head and neck cancer pathogenesis and progression. To ide...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.13
更新日期:2014-02-06 00:00:00
abstract::Inhibitor of apoptosis (IAP) proteins are a family comprised of a total of eight mammalian members that were initially described to act as endogenous inhibitors of caspases. In addition, extensive evidence has been accumulated over the last years showing that IAP proteins can regulate various signal transduction pathw...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.63
更新日期:2014-02-06 00:00:00